O'Neill is likely to make several alterations from the side that overcame Sunderland 2-1 at the weekend and £12million record signing Milner, Carlos Cuellar and Moustapha Salifou are all expected to be given the chance at Villa Park.
O'Neill confirmed: "The Chelsea game will have some bearing on the side I select. I hate to try and look forward but the side will have some bearing only because of the glut of games we have played.
"Some players, like Gareth Barry, have played a host of games, including the recent England games, without respite. Stiliyan Petrov has had a similar schedule so, as much as Thursday is important, I have to keep an eye on Sunday at the same time.
"But I would be devastated if we went out before reaching the group stages.
"I think Litex will come and attack us, which might create the odd chance for us, but I don't think they will feel out of it simply because of the way they played against us in the first match."




