Hashim Amla came into the tourists side for the injured captain Graeme Smith, with stand-in skipper Jacques Kallis winning the toss and putting England in to bat in the morning.
But Ian Bell (73) and Flintoff (78 not out) took England to 296-7, a total South Africa never threatened to reach.
Patel destroyed the lower order and took 5-41 with his left-arm spin, his best figures in all listed cricket, after he had earlier made 31.



